Proteinglycationandmethylglyoxalmetabolism inyeast: ¢nding peptideneedles in protein haystacks

Atranscriptomeanalysis of isoamylalcohol-induced¢lamentation inyeast reveals a novel role forGre2pas isovaleraldehyde reductase

inyeast reveals a novel role forGre2pas isovaleraldehyde reductase Michael Hauser, Patrick Horn, Helene Tournu, Nicole C. Hauser, Jörg D. Hoheisel, Alistair J. P. Brown & J. Richard Dickinson Cardiff School of Biosciences, Cardiff University, Cardiff, UK; School of Medical Sciences, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK; and Division of Functional Genome Analysis, ...

Exploring Big Haystacks: Data Mining and Knowledge Management

Guest Editors' Introduction: Information Discovery--Needles and Haystacks

For thousands of years, people have realized the importance of archiving and finding information. With the advent of computers, it became possible to store large amounts of information in electronic form — and finding useful needles in the resulting haystacks has since become one of the most important problems in information management. Many systems exist to help users navigate the considerable...

Genome-wideanalysis ofthe response to proteinglycosylation de¢ciency inyeast

Protein modification by glycosylation occurs through an essential biochemical pathway that produces mannosyl side chain substrates, which are covalently attached to proteins in the endoplasmic reticulum. We used DNA microarray analysis to characterize the cellular response to a conditional defect (pmi40-101) in the protein glycosylation pathway. Expression profiles were obtained from DNA microa...

Chapter 11 Min Cut

x To acknowledge the corn-This purely American expression means to admit the losing of an argument , especially in regard to a detail; to retract; to admit defeat. It is over a hundred years old. Andrew Stewart, a member of Congress, is said to have mentioned it in a speech in 1828. He said that haystacks and cornfields were sent by Indiana, Ohio and Kentucky to Philadelphia and New York. Charl...